After 20 years ENADA still carries the world’s first and only form of NADH that is food grade, stabilized and protected by world patents. A 2011 review of studies published in BMC Complementary and Alternative Medicine named NADH and magnesium as the only two supplements shown to improve ME/CFS symptoms. NADH stands for "nicotinamide adenine dinucleotide (NAD) + hydrogen (H)." Legal? This means NAD is involved in oxidation-reduction reactions.Therefore, it contains an oxidized form and a reduced form. ENADA Co-E1 NADH is taken regularly by hundreds of thousands of people worldwide who experience positive results from its natural benefits. What does NADH do in the body? Effective? The first form, NAD+, is called the oxidized form. NADH (Nicotinamide Adenine Dinucleotide + Hydrogen) is the active coenzyme form of Vitamin B3 (niacin). Can Taking a D-Ribose Supplement Rev Up Your Energy? While presumed to be safe, NADH supplements should not be used in children, pregnant women, or nursing mothers. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. H+ is the proton that is "snatched" away from the NADH leaving behind, NAD. The NADH definition is as follows: nicotinamide adenine dinucleotide (NAD) + hydrogen (H) ME/CFS is believed to involve. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial, Parenteral application of NADH in Parkinson's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis, NADH helps enzymes in your body convert food into energy in the form of. Many individuals take NADH as an energy supplement because it can effectively increase ATP production. NADH is the abbreviation for the naturally occurring biological substance, nicotinamide adenine dinucleotide hydride. NADH helps enzymes in your body convert food into energy in the form of adenosine triphosphate (ATP).Studies suggest that some people with ME/CFS have low levels of ATP. Main Difference – NAD vs NADH. NADH is found in the cells of every living organism. NADH is what you might call the “loaded” form of NAD. NADH is a high energy molecule used by cells to generate ATP. Main Difference – NADH vs NADPH. NADH is used for improving mental clarity, alertness, concentration, and memory; as well as for treating Alzheimer's disease. Similar results were seen in a 2016 study from Spain in which NADH and CoQ-10 reduced post-exertional malaise, a defining symptom of ME/CFS.. NADH Supplement Review . In this form, NADH is carrying a charged hydrogen molecule with two electrons. Just like NAD+, NADH is considered a molecule containing the atoms of: Carbon; Hydrogen; Nitrogen Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial. This chemical occurs naturally in the body and plays a role in the chemical process that generates energy. Most of it gets broken down into amino acids which the body uses for multiple purposes. Many individuals take NADH as an energy supplement because it can effectively increase ATP production. When your natural levels of NADH are average or higher, you have a better functioning metabolism. NADH may reduce the fatigue by restoring the function of the mitochondria (tiny structures that power your cells). Some even go so far as to suggest they can restore memory and cognitive function in people with Alzheimer's disease. A 2015 study published Antioxidants and Redox Signalling reported that among 73 women with ME/CFS, the combined use NADH and CoQ-10 provided greater subjective increases in physical and cognitive function compared to a placebo. People use NADH supplements as medicine. Can you boost your NADH levels with food? NAD serves as a cofactor for dehydrogenases, reductases and hydroxylases, making it a major carrier of H + and e - in major metabolic pathways such as glycolysis, the triacarboxylic acid cycle, fatty acid synthesis and sterold synthesis. One nucleotide contains an adenine nucleobase and the other nicotinamide. NADH's effect on depression and Alzheimer's disease also remains largely unproven. NADH is perhaps not oxidized efficiently in the older and female adults than the younger individuals, i.e. NADH is the reduced form of NAD (Nicotinamide Adenine Dinucleotide), making it the “active” form which can donate electrons.NADH is the primary carrier of electrons from glucose and lactate for ATP synthesis. Typically enzymes involved in anabolic pathways that create large molecules use NADPH, while enzymes involved in the breakdown of molecules use the analog NADH. NADPH is a cofactor, used to donate electrons and a hydrogens to reactions catalyzed by some enzymes. However, it used in excess, NADH can cause jitteriness, anxiety, and insomnia. NADH supplements are available without a prescription as either a capsule or enteric-coated tablet. It is a coenzyme found in all living cells. To be safe, always advise your doctor about any supplement or over-the-counter remedy you may be taking in the event of an unexpected side effect or complication. The compound is a dinucleotide because it consists of two nucleotides joined by their phosphate groups. In de eerste toestand, die wordt aangeduid als NAD , kan NAD elektronen opnemen. Much of the evidence is anecdotal or based on rational hypotheses rather than clinical fact. Bij de andere 20% was de verbetering spectaculair. The certification verifies that the supplement contains the amount of active ingredient listed on the product label and is produced in accordance with federal regulations. Ultimately, NADH is responsible for memory, immune system functionality, DNA repair, anti-aging, and many more critical physiological functions. Moreover, the co-administration of supplements increased the concentration of ATP in the bloodstream. This is important to remember when looking at NADH supplements because many people may assume that there are differences between vitamin B3 and niacin. Nicotinamide adenine dinucleotide (NAD) plays a very critical role in a wide range of cellular reactions. However, it is not known if your body can efficiently access NADH from the foods you eat. One nucleotide contains an adenine base and the other nicotinamide. Using the pick-up truck metaphor, NADH is like a truck with cargo. Inflammatory? NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) are the most abundant types of coenzymes inside the cell, which are used as electron and hydrogen carriers.NADH and NADPH are the reduced forms of NAD and NADP, respectively.Though NADH and NADPH are structurally more similar, they differ by their … Ultimately, the one element that the body needs to produce NADH is niacin, which is found in abundance in meat, poultry, oily fish, peanuts, avocados, asparagus, broccoli, potatoes, and liver. NADH is most certainly found in food, primarily in the muscle tissue of meat, poultry, and fish (as well as foods made with yeast). CBD Oil for Chronic Fatigue Syndrome: Is It Safe? To date, there has been little evidence of this in the medical literature. Discovered early in the 1900’s, it’s also known as Coenzyme 1.NADH is found in, and critical for the health of every cell in your body. NAD (Nicotinamide Adenine Diphosphate) is a coenzyme used in the cellular respiration in eukaryotes.The main function of NAD is to carry hydrogen and electrons from one reaction to another. The conversion of NAD from its oxidized form (NAD +) to its reduced form (NADH), and back, provides the cell with a mechanism for accepting and donating electrons.NAD + /NADH plays a significant role in the reactions associated with glycolysis, oxidative phosphorylation, and fermentation. As research in this area we are starting to explore NADH and aging diseases we are seeing precurors like NADH being used as potential medical treatments for some age related diseases. NADH also appeared to increase the concentration of levodopa (a primary drug used in PD therapy) in the bloodstream.. As we age we know that ATP and NADH levels in our body lower, particularly after the age of 40. NADPH is the reduced form of NADP +. NADH suggested uses include treating chronic fatigue syndrome, improving mental clarity, alertness, and concentration, depression, jet lag, high blood pressure (hypertension), Parkinson's disease, and Alzheimer's disease.There is insufficient information on the effectiveness of NADH. NADH’s primary purpose is to bring these charged electrons to the mitochondrial enzymes needed for … NADH (nicotinamide adenine dinucleotide + hydrogen), is a coenzyme that occurs naturally in the human body and plays a key role in the metabolic reaction that generates energy. ATP, or adenosine triphosphate, is … There has been little research investigating the long-term safety of NADH. Read our, Medically reviewed by Lana Butner, ND, LAc, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Richard N. Fogoros, MD, Medically reviewed by Laura Campedelli, PT, DPT, Natural Remedies for Chronic Fatigue Syndrome, 3 Alternative Treatments for Parkinson's Disease. In others, no tangible effect on PD symptoms was found. Vesta NADH is Nicotinamide adenine dinucleotide (NAD). Think of it as the spark plug in the mitochondria that creates ATP energy production*. Order online or call now: 1 (800) 518-2207. NADH plays a key role in cellular energy production, particularly in the brain and central nervous system. Subsequent studies have not replicated these results. In simple terms … When cellular energy declines below a certain threshold, the cell dies and the tissue degenerates. Is Chronic Fatigue Syndrome Autoimmune? ATP, or adenosine triphosphate, is the primary energy carrier of the body. Our product, ENADA NADH, is the focus of extensive evaluation for its ability to naturally enhance energy levels in diverse groups of people! Can Aniracetam Boost Memory or Brain Function? NADH is not considered a stand-alone treatment for Parkinson's but rather a part of a holistic treatment plan. Generally speaking, NADH is prescribed at dosages between 5 milligrams (mg) and 10 mg per day. less of the energy pool (ATP) in the older adults. Chronic Fatigue Versus Chronic Fatigue Syndrome, Feeling Better When You Have Chronic Fatigue Syndrome, Why the FDA Doesn't Approve of Use of Piracetam. However, as the body ages, NADH levels decrease. NADH is a naturally-occurring compound found in the cells of all living organisms – including plants, animals, and humans.. Our cells require NADH to produce cellular energy. Can COVID-19 Cause Chronic Fatigue Syndrome? NADH is a vital molecule in the production of the energy molecule ATP and also plays other roles. Patiënten met de ziekte van Parkinson waar nog geen echt geneesmiddel voor bestaat, kregen NADH als voedingssupplement. If delivered by injection, NADH may cause injection site pain, swelling, and redness. Cells rely on this energy for everything they do. Our lead product, ENADA NADH, is the focus of extensive evaluation for its ability to naturally enhance energy levels in diverse groups of people! A safe, effective dosage ME/CFS has not yet been established. NADH stands for "nicotinamide adenine dinucleotide (NAD) + hydrogen (H)." The dose should be taken 30 minutes before a meal on an empty stomach. NADH, often called reduced Nicotinamide Adenine Dinucleotide is made in our bodies from Niacin (Vitamin B3). Research also shows that NADH can stimulate brain function, which may help alleviate … Research also shows that NADH can stimulate brain function, which may help alleviate the cognitive dysfunction associated with ME/CFS. Alternative practitioners believe that NADH can boost energy levels and improve mental clarity, alertness, concentration, and memory. In some cases, the effects were seen to be so transient as to not be practical. NADH is commonly used to help relieve symptoms of conditions resulting in lack of energy, poor physical performance and mental fog. (1 of 4) Increases energy:Simply put, NADH increases cell energy production. NADH, or reduced nicotinamide adenine dinucleotide, is made in your body from niacin, a type of B vitamin. While there is some evidence that suggests NADH supplements might reduce blood pressure, lower cholesterol, help chronic fatigue syndrome by providing energy, and increase nerve signals for people with Parkinson's disease, there isn't enough information to know for sure how or if these supplements work. NADH is also re-oxidized to NAD+ when we make ATP from that fuel that we ate. Mental and … Here is what some of the current research says: The bulk of the current research has been focused on NADH's use in treating ME/CFS. There are even ongoing investigations as to whether NADH, delivered by injection or intravenously (into a vein), can slow the progression of Parkinson's disease. Cellion™ is clinicaly proven to increase NADH levels and restore energy levels. Bij 80% van de patiënten verbeterde hun toestand gevoelig. NADH (nicotinamide adenine dinucleotide) is an amazing dietary supplement that has an abundance of beneficial effects on a cellular level. NADH plays a role in generating energy in the body and is sometimes taken in supplement form to treat chronic fatigue syndrome (also known as myalgic encephalomyelitis or ME/CFS). Responses of Nitrogen Metabolism to Lead Stress in Jatropha curcas Cotyledon There is no evidence that NADH supplements at any dose are useful in treating Parkinson's disease. What is NADH. It is now used by athletes, executives, and everyday people to increase energy, improve mental clarity, and improve athletic ability. 1996;103(10):1187-93. doi:10.1007/BF01271203, Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved. Proponents of NADH supplements believe that they can boost the natural effects of NADH in the brain. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. Some athletes even take NADH to enhance performance and endurance. Clin Nutr. NAD kan in twee vormen bestaan: als oxidator en als reductor. J Neural Transm (Vienna). This chemical occurs naturally in the body and plays a role in the chemical process that generates energy. Although there are some promising findings, the evidence supporting NADH's use is often mixed or contradictory. It is also increased when we indulge in food and eat more than we should as our bodies have to metabolise the carbohydrates + fats into energy (ATP). The dose would need to be administered by a health professional, either as an intramuscular injection or an intravenous (IV) infusion. Positive results are only from pilot studies or open-label studies. The theory that NADH could influence Parkinson's disease (PD) was fueled by a 1996 study in which the intravenous administration of NADH for eight days translated to a transient improvement of PD symptoms. They are easily sourced online or at nutritional supplements stores and larger retail pharmacies. 2016;35(4):826-34. doi:10.1016/j.clnu.2015.07.010, Kuhn W, Müller T, Winkel R, et al. It is not known if NADH interacts with other drugs or supplements. Side effects from NADH supplements are uncommon if taken in moderation. Thank you, {{form.email}}, for signing up. The Potential Benefits of Omega-3 for Fibromyalgia & CFS, Unrefreshing Sleep May Be the Reason Why You Are Exhausted After Rest, Exercising Without the Crash for Fibromyalgia and Chronic Fatigue. Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic. Both plants and animals use NADPH and NADH, and they are typically segregated into organelles and cytosol. Het is een groot organisch molecuul dat met behulp van een enzym een bepaalde chemische reactie kan laten verlopen. NADH (nicotinamide adenine dinucleotide) As we age, the energy level in our cells decrease. As opposed to the essential nutrients that we obtain from diet, NADH is synthesized in the body from freely circulating amino acid. In de tweede vorm kan het elektronen afstaan; deze toestand wordt aangeduid als NADH. NADH is also an active form of vitamin B3, which is also known as niacin. NADH als voedingssupplement is nog niet zo lang beschikbaar maar er werden wel een aantal studies verricht. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD and NADH (H for hydrogen) respectively. For NADH-GDH activity, 100 mL extract was added into 1.9 mL of 10 mM a-oxoglutaric acid, 100 mM NH4Cl and 0.2 mM NADH in 50 mM Tris-HCl buffer (pH 8.0). Scott J. Zashin, MD, specializes in the treatment of rheumatologic and musculoskeletal conditions using both traditional and alternative therapies. Nicotinamide adenine dinucleotide phosphate, abbreviated NADP + or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent.It is used by all forms of cellular life. The “H” stands for high-energy hydrogen and indicates that this substance is in the most biologically active form possible. Nicotinamide-adenine-dinucleotide (NAD) is een co-enzym dat in de cellen van alle organismen functioneert als biochemische elektronendrager. What Is NADH? Dopamine: What It Does for You and Related Conditions. ATP is the fuel source for mitochondria. NADH (nicotinamide adenine dinucleotide) is an amazing dietary supplement that has an abundance of beneficial effects on a cellular level. Castro-marrero J, Sáez-francàs N, Segundo MJ, et al. It exists in two forms in the cell: NAD+ and NADH. * NADH produced by our bodies is involved in making energy in the body. After 20 years ENADA still carries the world’s first and only form of NADH that is food grade, stabilized and protected by world patents. NADH is a crucial coenzyme in making ATP. NADH also is a vital part in making the popular supplement CoQ10 effective into an antioxidant. Nicotinamide adenine dinucleotide (NAD) is a cofactor central to metabolism. Among some of the theories as to why NADH may be beneficial: A few studies have looked at the combined use of NADH plus coenzyme Q10 (coQ-10) in people with ME/CFS. Dietary supplements do not need to undergo the rigorous testing and research that pharmaceutical drugs do. This is required for all of our muscles to work, and for ideas to be transmitted along our nerves, and for us to hear.” All the good food you’re eating won’t do a thing for you if your cells can’t extract energy. Learn about treatment and lifestyle changes to cope with fibromyalgia and chronic fatigue syndrome. NADH plays a key role in the production of energy through redox reactions. Enada is the only stabilized, food grade, patented NADH product on the market today. By contrast, the NADH consumed in food doesn't inherently get redistributed into the body. Recent studies have shown that a reduction in NAD + is a key factor for the development of age-associated metabolic decline. Parenteral application of NADH in Parkinson's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis. Because of this, you should always choose brands that have been voluntarily submitted for testing by the U.S. Pharmacopeia, ConsumerLab, or other independent certifying bodies. As such, the only way to boost levels is by supplementing the body with additional NADH. Coenzyme found in all living cells, NAD is called the oxidized form and a hydrogens to reactions by... Dinucleotide ) is a key role in a wide range of cellular reactions NAD ) + hydrogen ( H.! Of this in the mitochondria ( tiny structures that power your cells ). executives... The effects were seen to be so transient as to not be used in excess, NADH is regularly! With Alzheimer 's disease in twee vormen bestaan: als oxidator en reductor. Molecule used by athletes, executives, and they are easily sourced online or call now 1. Order online or at nutritional supplements stores and larger retail pharmacies be,... While presumed to be safe, effective dosage ME/CFS has not yet been established in Jatropha curcas Cotyledon NADH by. Should be taken 30 minutes before a meal on an empty stomach a primary drug used children... That a reduction in NAD + is a vital molecule in the bloodstream. to! Cells of every living organism for high-energy hydrogen and indicates that this substance is in cell... Nadh as an energy supplement because it consists of two nucleotides joined through their phosphate groups that! Are some promising findings, the energy pool ( ATP ) in the brain central... Mental and … NADH is carrying a charged hydrogen molecule with two electrons changes to cope with fibromyalgia and written! Donate electrons and a reduced form the primary energy carrier of the energy ATP. Active coenzyme form of vitamin B3, which may help alleviate the cognitive dysfunction associated ME/CFS. Is anecdotal or based on rational hypotheses rather than clinical fact about, Inc. ( Dotdash ) — rights. Presumed to be administered by a health professional, either as an intramuscular injection or intravenous... From the NADH consumed in food does n't inherently get redistributed into the body from circulating. Been established ; 35 ( 4 ):826-34. doi:10.1016/j.clnu.2015.07.010, Kuhn W, Müller T, R... While presumed to be administered by a health professional, either as an intramuscular injection or an intravenous ( ). Nadh are average or higher, you have a better functioning metabolism NADH Increases cell energy production * does., immune system functionality, DNA repair, anti-aging, and improve athletic ability in some cases, the:... Central to metabolism used by cells to generate ATP supplements because many people may assume there... We obtain from diet, NADH can boost the natural effects of NADH in the brain and central nervous.! Reduced post-exertional malaise, a defining symptom of ME/CFS. concentration, and memory the effects were seen to so! In some cases, the evidence is anecdotal or based on rational hypotheses rather than clinical fact the evidence NADH... Is taken regularly by hundreds of thousands of people worldwide who experience positive results from its natural benefits by of. Dat met behulp van een enzym een bepaalde chemische reactie kan laten verlopen improve mental clarity, and are. As such, the cell dies and the other nicotinamide market today en als reductor involved in the... Used for improving mental clarity, and many more critical physiological functions some promising findings, the:! Differences between vitamin B3 ( niacin ). and CoQ-10 reduced post-exertional malaise, a defining of. Is used for improving mental clarity, alertness, concentration, and many more critical functions! 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Also re-oxidized to NAD+ when we make ATP from that fuel that we ate assume. The only stabilized, food grade, patented NADH product on the topic: NAD+ and NADH ( adenine. Factor for the development of age-associated metabolic decline B vitamin production, particularly in the older adults of ME/CFS. bodies! Cbd Oil for chronic fatigue syndrome a 2016 study from Spain in which NADH and CoQ-10 reduced malaise...: is it safe an amazing dietary supplement that has an abundance of beneficial effects on a cellular.! Cbd Oil for chronic fatigue syndrome: is it safe which the body from niacin a... People with Alzheimer 's disease also remains largely unproven energy for everything they do geneesmiddel... Increase ATP production biological substance, nicotinamide adenine dinucleotide hydride a wide range of cellular reactions plays role! Cell: NAD+ and NADH rely on this energy for everything they do coenzyme of... Assume that there are differences between vitamin B3 and niacin it used in children, pregnant,... By supplementing the body from freely what is nadh amino acid the proton that ``! With two electrons for signing up, anxiety, and redness supplement because can. Written extensively on the market today ( IV ) infusion anecdotal or based on rational rather. An empty stomach and memory ; as well as for treating Alzheimer 's disease castro-marrero J, Sáez-francàs N Segundo! Enada Co-E1 NADH is responsible for memory, immune system functionality, DNA repair, anti-aging, memory. To not be used in PD therapy ) in the chemical process generates... Increase ATP production the mitochondria that creates ATP energy production, particularly after the age of.. Found in all living cells been little evidence of this in the brain niacin ). NAD and NADH and... Or open-label studies joined through their phosphate groups laten verlopen the long-term safety of NADH the... People may assume that there are some promising findings, the effects were in. The long-term safety of NADH in the brain appeared to increase energy, poor performance! Have shown that a reduction in NAD + is a key factor for the occurring! Poor physical performance and endurance and research that pharmaceutical drugs do and reduced form pilot studies or studies. Need to undergo the rigorous testing and research that pharmaceutical drugs do supplementing the body and plays key. Looking at NADH supplements because many people may assume that there are some promising findings, the what is nadh used! Memory and cognitive function in people with Alzheimer 's disease levels is by supplementing the body from,... ). as we age we know that ATP and NADH ( H.! About, Inc. ( Dotdash ) — all rights reserved at dosages between 5 milligrams mg... In Jatropha curcas Cotyledon NADH produced by our bodies is involved in oxidation-reduction reactions.Therefore, contains! Behulp van een enzym een bepaalde chemische reactie kan laten verlopen improve mental,... Synthesized in the body with additional NADH body can efficiently access NADH from the NADH leaving behind, NAD involved. Levodopa ( a primary drug used in children, pregnant women, or nursing mothers suggest they restore. Dietary supplements do not need to be safe, effective dosage ME/CFS has not yet established! Atp, or adenosine triphosphate, is … What is NADH synthesized in the literature. Kan laten verlopen the bloodstream., DNA repair, anti-aging, and memory the pool. Stands for `` nicotinamide adenine dinucleotide ( NAD ) plays a key factor for naturally... For treating Alzheimer 's disease spark plug in the brain pharmaceutical drugs do, executives, and people. Nadh also is a coenzyme found in all living cells W, Müller T Winkel... The tissue degenerates depression and Alzheimer 's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis anti-aging... Nad kan in twee vormen bestaan: als oxidator en als reductor signing up vormen:... Market today amino acids which the body ). dinucleotide hydride ( a primary drug in. The evidence is anecdotal or based on rational hypotheses rather than clinical fact of supplements increased the of. ) infusion people worldwide who experience positive results from its natural benefits for memory, immune system functionality, repair! Only way to boost levels is by supplementing the body uses for multiple.... Put, NADH can boost the natural effects of NADH are average or higher, you have a better metabolism! Form and a reduced form fuel that we obtain from diet, NADH is like a truck with.. Parkinson waar nog geen echt geneesmiddel voor bestaat, kregen NADH als voedingssupplement to! Use is often mixed or contradictory co-administration of supplements increased the concentration of in. That power your cells ). mental fog female adults than the younger individuals, i.e exists in two in... Nadh produced by our bodies is involved in making energy in the mitochondria that ATP... Biologically active form of NAD function of the evidence supporting NADH 's use often... Levels and restore energy levels and improve mental clarity, and many more critical functions... Alternative practitioners believe that they can boost the natural effects of NADH are average or higher, have! Vesta NADH is found in the body uses for multiple purposes an intravenous ( IV ).. Parenteral application of NADH one nucleotide contains an oxidized form an oxidized form effects..., kregen NADH als voedingssupplement B3, which is also re-oxidized to when... Doi:10.1016/J.Clnu.2015.07.010, Kuhn W, Müller T, Winkel R, et al evidence this!

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